介绍：在上一集101真狗中，古拉（格伦•克洛斯 饰）被关进了牢狱中三年牢狱中古拉提前出狱了，本来以为她会改过自身不在打那些可爱斑点狗的主意，就连她自己也说不会再做杀害斑点狗的残忍事。　　但她的虚荣心还是敌不过自己的意志，看到那些美丽的斑点狗，她再次动心想要取得那些斑点狗的皮毛。法国设计师勾画出的美丽服装设计图，再次让她决定故伎重演的决心。102只斑点狗的生命危在旦夕，但这些懂人性小狗们为了自己家族的生命，也要抵抗到底。在斗争的过程中，一只刚出生的小狗，成为了大英雄。

介绍：A mathematician and author, Luke Williams, is travelling up to London on a train when he meets a old lady, Lavinia Fullerton, who is also going to London, to Scotland Yard. Lavinia tells Luke that in her small village several people have died. The local police are certain that it was all accidental and are taking no action but Lavinia isn't convinced. In London Luke watches, horrified, as Lavinia is run over in a hit and run and he becomes convinced that she was telling the truth. He travels down to the village and with the aid of a local girl, who is also convinced that the deaths were murder, sets out to solve the mystery.